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Stock Information

Shareholder Breakdown
Shareholder Holders Values ($) % O/S Shares
Institution 198 666 97.28 42,230,244
Mutual Fund 185 215 33.58 14,576,471
Institutional Shareholder Rotation
Shareholder Holders Values Change ($) % O/S Shares Change
Buyers 107 95.87 14.50 6,294,164
Sellers 116 -99.16 15.08 -6,547,583
Net -- -3.29 0.58 -253,419
Institutional Shareholder Concentration
Shareholder Values ($) % O/S Shares
Top 10 Inst. 402 57.95 25,154,386
Top 20 Inst. 532.77 77.07 33,455,599
Top 50 Inst. 625.38 91.22 39,597,583
Total Inst. 625.38 91.22 39,597,583
Institutional Shareholder Style
Shareholder Holders Values ($) % O/S Shares
Index 25 117 22.45 7,751,522
Growth 11 75 14.42 4,979,660
CoreGrowth 34 23 4.39 1,516,053
GARP 28 145 27.77 9,590,733
HedgeFund 23 63 12.08 4,170,101
VCPrivateEquity 1 56 10.70 3,695,205
BrokerDealer 19 9 1.66 574,565
Specialty 1 2 0.32 112,000
IncomeValue 1 1 0.27 93,386
Yield 1 0 0.00 1,174
CoreValue 13 8 1.51 519,814
DeepValue 9 5 0.87 301,686
Top Holders: Institutional Investor
Holder Shares Held % O/S Shares Change Filing Date
Fidelity Management & Research Company 6,490,236 14.95 2,155 12/31/2016
Alafi Capital Company, LLC 3,695,205 8.51 99,000 12/07/2016
BlackRock Institutional Trust Company, N.A. 2,975,016 6.85 1,043,047 12/31/2016
Sosland (Morton I) 2,638,389 6.08 -1,000,080 12/31/2016
The Vanguard Group, Inc. 2,555,722 5.89 96,351 12/31/2016
Bellevue Asset Management AG 1,575,000 3.63 225,000 12/31/2016
TimesSquare Capital Management, LLC 1,534,938 3.54 -221,637 12/31/2016
Citadel LLC 1,263,482 2.91 1,206,185 12/31/2016
Alafi (Christopher D) 1,235,242 2.85 960 12/30/2016
Alexandria Equities, L.L.C. 1,191,156 2.74 -92,700 04/15/2016
Mates (Sharon) 1,088,707 2.51 2,522 01/05/2017
Mates (Sharon Ph.D.) 1,068,935 2.46 15,000 04/15/2015
Jennison Associates LLC 1,024,366 2.36 -289,150 12/31/2016
Wasatch Advisors, Inc. 1,014,948 2.34 258,937 12/31/2016
Hillhouse Capital Management Ltd. 1,000,000 2.30 0 12/31/2016
State Street Global Advisors (US) 972,868 2.24 148,745 12/31/2016
Baker Bros. Advisors LP 609,166 1.40 0 12/31/2016
Columbus Circle Investors 519,108 1.20 128,458 12/31/2016
T. Rowe Price Associates, Inc. 516,622 1.19 -47,080 12/31/2016
Millennium Management LLC 486,493 1.12 105,290 12/31/2016
Bogle Investment Management, L.P. 453,534 1.04 453,534 12/31/2016
Morgan Stanley Wealth Management 386,387 0.89 -45,744 12/31/2016
Northern Trust Investments, Inc. 377,970 0.87 15,637 12/31/2016
Sarissa Capital Management, L.P. 360,000 0.83 -315,000 12/31/2016
Clough Capital Partners, LP 349,650 0.81 177,800 12/31/2016
BlackRock Financial Management, Inc. 300,625 0.69 3,051 12/31/2016
Rhenman & Partners Asset Management AB 290,000 0.67 155,000 12/31/2016
General American Investors Company, Inc. 284,942 0.66 55,000 12/31/2016
Norges Bank Investment Management (NBIM) 280,850 0.65 280,850 12/31/2016
Geode Capital Management, L.L.C. 262,759 0.61 15,767 12/31/2016
Riggs (Rory B) 259,300 0.60 960 12/30/2016
Deutsche Asset Management Americas 234,373 0.54 232,186 12/31/2016
TIAA Global Asset Management 213,207 0.49 -6,229 12/31/2016
Rock Springs Capital Management LP 190,000 0.44 0 12/31/2016
Weiss Multi-Strategy Advisers LLC 180,000 0.41 165,000 12/31/2016
Deutsche Asset Management Investment GmbH 148,359 0.34 2,632 12/31/2016
BlackRock Investment Management, LLC 144,713 0.33 179 12/31/2016
Charles Schwab Investment Management, Inc. 130,640 0.30 6,709 12/31/2016
Pictet Asset Management Ltd. 123,108 0.28 15,460 12/31/2016
Susquehanna Financial Group, LLLP 120,263 0.28 120,263 12/31/2016
D. E. Shaw & Co., L.P. 118,390 0.27 81,469 12/31/2016
Candriam Luxembourg S.A. 117,000 0.27 7,000 12/31/2016
Candriam Belgium S.A. 117,000 0.27 0 01/31/2017
SEI Investments Management Corporation 112,000 0.26 -1,548 12/31/2016
Morgan Stanley & Co. LLC 104,657 0.24 91,773 12/31/2016
Frontier Capital Management Company, LLC 100,184 0.23 -6,397 12/31/2016
A.R.T. Advisors, LLC 99,300 0.23 99,300 12/31/2016
Carnegie Asset Management Fondsmæglerselskab A/S 96,048 0.22 28,548 12/31/2016
BNY Mellon Asset Management 93,386 0.22 -8,326 12/31/2016
J.P. Morgan Securities LLC 93,339 0.22 93,339 12/31/2016

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