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STOCK INFORMATION

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 211 819.99 95.73 52,247,133
Mutual Fund 212 271.44 32.36 17,663,472
Insider 11 94.21 10.95 5,978,540

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 115 210.72 24.42 13,326,174
Sellers 73 -67.40 8.24 -4,496,867
Net -- 143.32 16.18 8,829,307

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 819.99 95.73 52,247,133
Top 10 Inst. 457.03 53.41 29,147,577
Top 20 Inst. 603.98 70.75 38,615,508
Top 50 Inst. 749.04 87.66 47,845,250

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 47 86.49 9.84 5,370,553
Aggressive Growth 3 0.63 0.07 40,129
Core Growth 33 40.33 4.68 2,554,156
Growth 11 45.52 5.09 2,776,268
Income 2 1.57 0.18 99,601
Income Value 1 1.46 0.17 92,740
Yield 1 0.11 0.01 6,861
Index 23 136.64 15.87 8,659,537
Momentum 1 0.02 -- 1,625
Other 84 458.78 53.37 29,126,973
Broker Dealer 18 43.32 5.03 2,745,271
GARP 27 185.51 21.55 11,758,971
Hedge Fund 38 168.32 19.55 10,669,461
VC/Private Equi 1 61.63 7.24 3,953,270
Value 23 14.84 1.74 951,394
Core Value 16 11.72 1.39 759,616
Deep Value 7 3.12 0.35 191,778

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 7,965,260 14.59 1,452,189 9/30/17
Alafi Capital Company, LLC 3,953,270 7.24 258,065 10/2/17
The Vanguard Group, Inc. 3,466,253 6.35 744,521 9/30/17
BlackRock Institutional Trust Company, N.A. 3,103,141 5.69 -212,097 9/30/17
Sosland (Morton I) 2,638,389 4.83 -1,000,080 12/31/16
Bellevue Asset Management AG 2,240,000 4.10 50,000 9/30/17
Wasatch Advisors, Inc. 1,970,181 3.61 310,668 9/30/17
Millennium Management LLC 1,382,964 2.53 1,382,964 9/30/17
Alafi (Christopher D) 1,248,219 2.29 10,000 11/22/17
Rhenman & Partners Asset Management AB 1,179,900 2.16 346,746 9/30/17
Alexandria Equities, L.L.C. 1,143,731 2.10 -47,425 4/15/17
Mates (Sharon) 1,107,457 2.03 18,750 10/30/17
Susquehanna Financial Group, LLLP 1,105,027 2.02 991,287 9/30/17
Hillhouse Capital Management Ltd. 1,000,000 1.83 -- 9/30/17
BVF Partners L.P. 950,000 1.74 950,000 9/30/17
Dimensional Fund Advisors, L.P. 938,980 1.72 291,793 9/30/17
Perceptive Advisors LLC 929,460 1.70 929,460 9/30/17
Bank of America Merrill Lynch (US) 805,834 1.48 -125,663 9/30/17
Samlyn Capital, LLC 749,679 1.37 212,479 9/30/17
State Street Global Advisors (US) 737,763 1.35 -266,597 9/30/17
Clough Capital Partners, LP 658,750 1.21 281,900 9/30/17
Baker Bros. Advisors LP 609,166 1.12 -- 9/30/17
Laurion Capital Management LP 550,000 1.01 550,000 9/30/17
Alyeska Investment Group, L.P. 548,955 1.01 548,955 9/30/17
Deutsche Asset Management Americas 491,707 0.90 -2,610 9/30/17
Morgan Stanley Wealth Management 416,603 0.76 21,070 9/30/17
Renaissance Technologies LLC 401,600 0.74 151,000 9/30/17
JP Morgan Asset Management 390,425 0.72 390,425 9/30/17
Northern Trust Investments, Inc. 375,088 0.69 8,585 9/30/17
Tourbillon Capital Partners, LP 375,000 0.69 375,000 9/30/17
Geode Capital Management, L.L.C. 337,189 0.62 50,659 9/30/17
HBK Investments, L.P. 300,000 0.55 300,000 9/30/17
DekaBank Deutsche Girozentrale 289,200 0.53 -- 9/30/17
General American Investors Company, Inc. 284,942 0.52 -- 9/30/17
Norges Bank Investment Management (NBIM) 280,850 0.51 -- 12/31/16
Riggs (Rory B) 262,277 0.48 918 9/29/17
Point72 Asset Management, L.P. 260,700 0.48 260,700 9/30/17
C WorldWide Asset Management Fondsmaeglerselskab A/S 242,156 0.44 24,194 9/30/17
Goldman Sachs & Company, Inc. 227,624 0.42 -353,146 9/30/17
Monashee Investment Management, LLC 194,000 0.36 194,000 9/30/17
Rock Springs Capital Management LP 187,500 0.34 -- 9/30/17
First Midwest Trust Company 184,836 0.34 28,487 9/30/17
Marcus (Joel S) 179,838 0.33 142,425 4/15/17
Deutsche Asset Management Investment GmbH 177,432 0.33 29,694 9/30/17
Candriam Belgium S.A. 177,000 0.32 -- 10/31/17
Candriam Luxembourg S.A. 177,000 0.32 22,000 9/30/17
Nuveen LLC 170,650 0.31 -2,890 9/30/17
Morgan Stanley & Co. LLC 166,330 0.30 95,655 9/30/17
Columbus Circle Investors 157,305 0.29 157,305 9/30/17
Federated MDTA LLC 155,619 0.29 -27,416 9/30/17

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