| Fidelity Management & Research Company LLC |
11,609,399 |
14.48 |
3,127,526 |
9/30/20 |
| The Vanguard Group, Inc. |
6,229,298 |
7.77 |
958,854 |
9/30/20 |
| Wasatch Global Investors Inc |
5,408,879 |
6.75 |
1,748,285 |
9/30/20 |
| Alafi Capital Company, LLC |
4,673,270 |
5.83 |
-- |
3/25/20 |
| BlackRock Institutional Trust Company, N.A. |
4,465,036 |
5.57 |
253,963 |
9/30/20 |
| Bellevue Asset Management AG |
3,579,919 |
4.47 |
-200,000 |
9/30/20 |
| Marshall Wace LLP |
3,492,678 |
4.36 |
2,174,748 |
9/30/20 |
| Millennium Management LLC |
1,995,896 |
2.49 |
1,808,241 |
9/30/20 |
| Samlyn Capital, LLC |
1,732,365 |
2.16 |
553,798 |
9/30/20 |
| Dimensional Fund Advisors, L.P. |
1,548,152 |
1.93 |
-51,341 |
9/30/20 |
| State Street Global Advisors (US) |
1,419,918 |
1.77 |
55,382 |
9/30/20 |
| Alexandria Venture Investments LLC |
1,191,156 |
1.49 |
-- |
3/25/20 |
| Mates (Sharon) |
1,113,392 |
1.39 |
-100,000 |
11/10/20 |
| Citadel Advisors LLC |
1,083,562 |
1.35 |
582,002 |
9/30/20 |
| Alafi (Christopher D) |
1,019,589 |
1.27 |
613 |
9/30/20 |
| Geode Capital Management, L.L.C. |
1,003,364 |
1.25 |
160,340 |
9/30/20 |
| Schroder Investment Management North America Inc. |
999,897 |
1.25 |
-119,645 |
9/30/20 |
| TimesSquare Capital Management, LLC |
902,500 |
1.13 |
897,800 |
9/30/20 |
| Northern Trust Investments, Inc. |
814,751 |
1.02 |
75,428 |
9/30/20 |
| Nuveen LLC |
791,036 |
0.99 |
104,018 |
9/30/20 |
| ClearBridge Investments, LLC |
646,521 |
0.81 |
20,379 |
9/30/20 |
| Alyeska Investment Group, L.P. |
556,312 |
0.69 |
287,912 |
9/30/20 |
| Point72 Asset Management, L.P. |
555,643 |
0.69 |
555,643 |
9/30/20 |
| Sofinnova Investments, Inc |
503,555 |
0.63 |
261,647 |
9/30/20 |
| Morgan Stanley Smith Barney LLC |
492,328 |
0.61 |
22,784 |
9/30/20 |
| Suvretta Capital Management, LLC |
492,270 |
0.61 |
492,270 |
9/30/20 |
| Assenagon Asset Management S.A. |
475,894 |
0.59 |
209,143 |
9/30/20 |
| Rhenman & Partners Asset Management AB |
475,000 |
0.59 |
-- |
9/30/20 |
| Nicholas Investment Partners, L.P. |
457,720 |
0.57 |
457,720 |
9/30/20 |
| Macquarie Investment Management |
450,000 |
0.56 |
170,000 |
9/30/20 |
| Charles Schwab Investment Management, Inc. |
443,373 |
0.55 |
77,997 |
9/30/20 |
| Candriam Belgium S.A. |
430,000 |
0.54 |
-140,000 |
9/30/20 |
| DCF Advisers, LLC |
427,000 |
0.53 |
1,500 |
9/30/20 |
| Adage Capital Management, L.P. |
400,000 |
0.50 |
400,000 |
9/30/20 |
| Riggs (Rory B) |
387,652 |
0.48 |
613 |
9/30/20 |
| General American Investors Company, Inc. |
347,497 |
0.43 |
80,970 |
9/30/20 |
| BlackRock Advisors (UK) Limited |
338,428 |
0.42 |
28,407 |
10/31/20 |
| BlackRock Asset Management Ireland Limited |
321,424 |
0.40 |
49,571 |
9/30/20 |
| Susquehanna International Group, LLP |
314,224 |
0.39 |
72,502 |
9/30/20 |
| T. Rowe Price Associates, Inc. |
313,346 |
0.39 |
-648,403 |
9/30/20 |
| Pinnacle Associates Ltd. |
264,180 |
0.33 |
-11,595 |
9/30/20 |
| Invesco Capital Management LLC |
256,351 |
0.32 |
-2,056 |
9/30/20 |
| Ikarian Capital LLC |
240,989 |
0.30 |
233,787 |
9/30/20 |
| First Midwest Trust Company |
230,203 |
0.29 |
-40,016 |
9/30/20 |
| D. E. Shaw & Co., L.P. |
229,603 |
0.29 |
48,518 |
9/30/20 |
| Pictet Asset Management Ltd. |
228,334 |
0.28 |
16,110 |
9/30/20 |
| Fidelity Institutional Asset Management |
227,943 |
0.28 |
180,210 |
9/30/20 |
| BlackRock Investment Management, LLC |
225,092 |
0.28 |
370 |
9/30/20 |
| Norges Bank Investment Management (NBIM) |
223,810 |
0.28 |
-59,695 |
12/31/19 |
| CaaS Capital Management LP |
198,494 |
0.25 |
198,494 |
9/30/20 |
