| Fidelity Management & Research Company |
7,694,912 |
11.58 |
1,391,790 |
3/31/20 |
| The Vanguard Group, Inc. |
5,259,830 |
7.92 |
1,040,240 |
3/31/20 |
| Alafi Capital Company, LLC |
4,673,270 |
7.03 |
-- |
3/25/20 |
| BlackRock Institutional Trust Company, N.A. |
3,989,290 |
6.00 |
475,225 |
3/31/20 |
| Bellevue Asset Management AG |
3,731,819 |
5.62 |
273,400 |
3/31/20 |
| Wasatch Global Investors Inc |
2,932,265 |
4.41 |
1,150,566 |
3/31/20 |
| Consonance Capital Management LP |
1,654,600 |
2.49 |
-320,400 |
3/31/20 |
| Dimensional Fund Advisors, L.P. |
1,634,982 |
2.46 |
-66,391 |
3/31/20 |
| T. Rowe Price Associates, Inc. |
1,494,485 |
2.25 |
201,249 |
3/31/20 |
| State Street Global Advisors (US) |
1,234,814 |
1.86 |
121,370 |
3/31/20 |
| Mates (Sharon) |
1,213,392 |
1.83 |
-- |
3/25/20 |
| Alexandria Venture Investments LLC |
1,191,156 |
1.79 |
-- |
3/25/20 |
| Samlyn Capital, LLC |
1,153,396 |
1.74 |
886,696 |
3/31/20 |
| Schroder Investment Management North America Inc. |
1,117,833 |
1.68 |
364,938 |
3/31/20 |
| Alafi (Christopher D) |
1,018,976 |
1.53 |
613 |
6/30/20 |
| Candriam Belgium S.A. |
893,000 |
1.34 |
-25,000 |
12/31/19 |
| The St. Louis Trust Company |
881,056 |
1.33 |
881,056 |
3/31/20 |
| Geode Capital Management, L.L.C. |
806,602 |
1.21 |
167,104 |
3/31/20 |
| Marshall Wace LLP |
684,778 |
1.03 |
684,778 |
3/31/20 |
| Northern Trust Investments, Inc. |
609,801 |
0.92 |
86,633 |
3/31/20 |
| Nuveen LLC |
579,493 |
0.87 |
236,929 |
3/31/20 |
| Rhenman & Partners Asset Management AB |
567,534 |
0.85 |
67,534 |
3/31/20 |
| ClearBridge Investments, LLC |
511,378 |
0.77 |
193,769 |
3/31/20 |
| Alyeska Investment Group, L.P. |
477,426 |
0.72 |
477,426 |
3/31/20 |
| Morgan Stanley Smith Barney LLC |
469,351 |
0.71 |
-3,740 |
3/31/20 |
| Millennium Management LLC |
456,133 |
0.69 |
196,279 |
3/31/20 |
| DCF Advisers, LLC |
432,500 |
0.65 |
-35,573 |
3/31/20 |
| Goldman Sachs & Company, Inc. |
404,118 |
0.61 |
237,011 |
3/31/20 |
| Riggs (Rory B) |
387,039 |
0.58 |
14,618 |
6/30/20 |
| Charles Schwab Investment Management, Inc. |
339,286 |
0.51 |
60,162 |
3/31/20 |
| Invesco Capital Management LLC |
290,365 |
0.44 |
262,693 |
3/31/20 |
| Susquehanna International Group, LLP |
286,899 |
0.43 |
279,931 |
3/31/20 |
| Elk Creek Partners, LLC |
274,034 |
0.41 |
274,034 |
3/31/20 |
| General American Investors Company, Inc. |
266,527 |
0.40 |
-65,000 |
3/31/20 |
| BlackRock Advisors (UK) Limited |
264,828 |
0.40 |
235,354 |
6/30/20 |
| Citadel Advisors LLC |
259,387 |
0.39 |
-361,527 |
3/31/20 |
| Ikarian Capital LLC |
249,002 |
0.37 |
249,002 |
3/31/20 |
| Pictet Asset Management Ltd. |
235,924 |
0.36 |
89,100 |
3/31/20 |
| Macquarie Investment Management |
235,000 |
0.35 |
135,000 |
3/31/20 |
| Norges Bank Investment Management (NBIM) |
223,810 |
0.34 |
-106,260 |
12/31/19 |
| First Manhattan Company |
197,700 |
0.30 |
197,700 |
3/31/20 |
| BlackRock Investment Management, LLC |
189,458 |
0.29 |
16,144 |
3/31/20 |
| D. E. Shaw & Co., L.P. |
186,447 |
0.28 |
-44,966 |
3/31/20 |
| BlackRock Financial Management, Inc. |
178,896 |
0.27 |
19,939 |
3/31/20 |
| First Midwest Trust Company |
174,594 |
0.26 |
72,705 |
3/31/20 |
| Renaissance Technologies LLC |
151,400 |
0.23 |
151,400 |
3/31/20 |
| Atom Investors LP |
151,239 |
0.23 |
151,239 |
3/31/20 |
| Laurion Capital Management LP |
150,000 |
0.23 |
150,000 |
3/31/20 |
| Assenagon Asset Management S.A. |
146,139 |
0.22 |
127,194 |
3/31/20 |
| Nexthera Capital LP |
143,665 |
0.22 |
143,665 |
6/30/19 |
