| Fidelity Management & Research Company LLC |
10,928,571 |
11.84 |
-1,041,794 |
9/30/21 |
| Wasatch Global Investors Inc |
8,319,212 |
9.01 |
196,208 |
11/30/21 |
| The Vanguard Group, Inc. |
6,891,569 |
7.46 |
63,132 |
9/30/21 |
| BlackRock Institutional Trust Company, N.A. |
4,761,042 |
5.16 |
5,211 |
9/30/21 |
| Alafi Capital Company, LLC |
4,743,770 |
5.14 |
70,500 |
4/1/21 |
| Bellevue Asset Management AG |
3,773,919 |
4.09 |
164,000 |
9/30/21 |
| Marshall Wace LLP |
2,295,634 |
2.49 |
-475,670 |
9/30/21 |
| Lord, Abbett & Co. LLC |
2,088,034 |
2.26 |
-57,554 |
9/30/21 |
| TimesSquare Capital Management, LLC |
1,718,665 |
1.86 |
565,285 |
9/30/21 |
| State Street Global Advisors (US) |
1,563,375 |
1.69 |
63,346 |
9/30/21 |
| Franklin Advisers, Inc. |
1,358,686 |
1.47 |
7 |
9/30/21 |
| Geode Capital Management, L.L.C. |
1,272,720 |
1.38 |
19,518 |
9/30/21 |
| Samlyn Capital, LLC |
1,263,716 |
1.37 |
136,101 |
9/30/21 |
| Suvretta Capital Management, LLC |
1,251,946 |
1.36 |
213,176 |
9/30/21 |
| Alexandria Venture Investments LLC |
1,191,156 |
1.29 |
-- |
4/1/21 |
| Citadel Advisors LLC |
1,176,465 |
1.27 |
-384,927 |
9/30/21 |
| Schroder Investment Management North America Inc. |
1,149,341 |
1.24 |
-155,849 |
9/30/21 |
| Mates (Sharon) |
1,094,467 |
1.19 |
-- |
1/10/22 |
| Alafi (Christopher D) |
1,020,548 |
1.11 |
-- |
4/1/21 |
| Millennium Management LLC |
737,151 |
0.80 |
94,173 |
9/30/21 |
| Dimensional Fund Advisors, L.P. |
731,479 |
0.79 |
124,045 |
9/30/21 |
| Northern Trust Investments, Inc. |
669,517 |
0.73 |
-22,639 |
9/30/21 |
| Nuveen LLC |
640,819 |
0.69 |
-48,865 |
9/30/21 |
| Nicholas Investment Partners, L.P. |
613,212 |
0.66 |
14,951 |
9/30/21 |
| Brandywine Global Investment Management, LLC |
585,074 |
0.63 |
389,514 |
9/30/21 |
| Norges Bank Investment Management (NBIM) |
527,281 |
0.57 |
176,658 |
12/31/20 |
| Goldman Sachs Asset Management, L.P. |
525,952 |
0.57 |
-155,275 |
9/30/21 |
| BlackRock Asset Management Ireland Limited |
523,325 |
0.57 |
25,919 |
9/30/21 |
| BlackRock Advisors (UK) Limited |
521,034 |
0.56 |
3,114 |
12/31/21 |
| Charles Schwab Investment Management, Inc. |
509,500 |
0.55 |
18,487 |
9/30/21 |
| Candriam Belgium S.A. |
485,466 |
0.53 |
165,979 |
9/30/21 |
| Macquarie Investment Management |
450,000 |
0.49 |
-- |
9/30/21 |
| ClearBridge Investments, LLC |
433,318 |
0.47 |
-40,075 |
9/30/21 |
| Rhenman & Partners Asset Management AB |
429,728 |
0.47 |
-- |
9/30/21 |
| Morgan Stanley Smith Barney LLC |
423,636 |
0.46 |
6,576 |
9/30/21 |
| DCF Advisers, LLC |
379,000 |
0.41 |
4,000 |
9/30/21 |
| General American Investors Company, Inc. |
350,804 |
0.38 |
-- |
9/30/21 |
| Russell Investments Trust Company |
330,859 |
0.36 |
-10,970 |
12/31/21 |
| Tekla Capital Management LLC |
324,401 |
0.35 |
121,645 |
9/30/21 |
| Morgan Stanley & Co. LLC |
311,544 |
0.34 |
67,080 |
9/30/21 |
| Riggs (Rory B) |
303,485 |
0.33 |
300 |
12/31/21 |
| Adage Capital Management, L.P. |
300,000 |
0.32 |
-300,000 |
9/30/21 |
| SEB Investment Management AB |
292,463 |
0.32 |
-- |
9/30/21 |
| BMO Family Office, LLC |
288,702 |
0.31 |
-114 |
9/30/21 |
| Credit Suisse Securities (USA) LLC |
253,520 |
0.27 |
252,299 |
9/30/21 |
| Eversept Partners, LP |
230,744 |
0.25 |
113,282 |
9/30/21 |
| Sofinnova Investments, Inc |
227,419 |
0.25 |
-85,740 |
9/30/21 |
| Vantage Consulting Group, Inc. |
226,670 |
0.25 |
-- |
9/30/21 |
| Pinnacle Associates Ltd. |
217,888 |
0.24 |
-7,610 |
9/30/21 |
| Parametric Portfolio Associates LLC |
215,195 |
0.23 |
-20,676 |
9/30/21 |
