| Fidelity Management & Research Company LLC |
11,799,543 |
14.72 |
190,144 |
12/31/20 |
| The Vanguard Group, Inc. |
6,481,344 |
8.09 |
252,046 |
12/31/20 |
| Wasatch Global Investors Inc |
6,333,900 |
7.90 |
925,021 |
12/31/20 |
| BlackRock Institutional Trust Company, N.A. |
5,034,106 |
6.28 |
569,070 |
12/31/20 |
| Alafi Capital Company, LLC |
4,673,270 |
5.83 |
-- |
3/25/20 |
| Bellevue Asset Management AG |
3,659,919 |
4.57 |
80,000 |
12/31/20 |
| Marshall Wace LLP |
3,496,033 |
4.36 |
3,355 |
12/31/20 |
| Samlyn Capital, LLC |
1,659,938 |
2.07 |
-72,427 |
12/31/20 |
| State Street Global Advisors (US) |
1,612,601 |
2.01 |
192,683 |
12/31/20 |
| Millennium Management LLC |
1,594,153 |
1.99 |
-401,743 |
12/31/20 |
| Citadel Advisors LLC |
1,425,686 |
1.78 |
342,124 |
12/31/20 |
| Schroder Investment Management North America Inc. |
1,313,026 |
1.64 |
313,129 |
12/31/20 |
| Alexandria Venture Investments LLC |
1,191,156 |
1.49 |
-- |
3/25/20 |
| Dimensional Fund Advisors, L.P. |
1,177,771 |
1.47 |
-370,381 |
12/31/20 |
| Mates (Sharon) |
1,133,392 |
1.41 |
-- |
2/19/21 |
| Geode Capital Management, L.L.C. |
1,107,996 |
1.38 |
104,632 |
12/31/20 |
| Alafi (Christopher D) |
1,020,084 |
1.27 |
495 |
12/31/20 |
| Suvretta Capital Management, LLC |
905,970 |
1.13 |
413,700 |
12/31/20 |
| TimesSquare Capital Management, LLC |
889,200 |
1.11 |
-13,300 |
12/31/20 |
| Sofinnova Investments, Inc |
848,162 |
1.06 |
344,607 |
12/31/20 |
| Northern Trust Investments, Inc. |
796,268 |
0.99 |
-18,483 |
12/31/20 |
| Nuveen LLC |
778,319 |
0.97 |
-12,717 |
12/31/20 |
| Adage Capital Management, L.P. |
762,417 |
0.95 |
362,417 |
12/31/20 |
| ClearBridge Investments, LLC |
621,745 |
0.78 |
-24,776 |
12/31/20 |
| Goldman Sachs & Company, Inc. |
552,451 |
0.69 |
455,872 |
12/31/20 |
| Rhenman & Partners Asset Management AB |
500,000 |
0.62 |
25,000 |
12/31/20 |
| Charles Schwab Investment Management, Inc. |
457,962 |
0.57 |
14,589 |
12/31/20 |
| Macquarie Investment Management |
450,000 |
0.56 |
-- |
12/31/20 |
| BlackRock Advisors (UK) Limited |
445,602 |
0.56 |
60,632 |
1/31/21 |
| Candriam Belgium S.A. |
430,000 |
0.54 |
-140,000 |
9/30/20 |
| DCF Advisers, LLC |
424,500 |
0.53 |
-2,500 |
12/31/20 |
| Morgan Stanley Smith Barney LLC |
418,810 |
0.52 |
-73,518 |
12/31/20 |
| Nicholas Investment Partners, L.P. |
390,289 |
0.49 |
-67,431 |
12/31/20 |
| Riggs (Rory B) |
388,147 |
0.48 |
495 |
12/31/20 |
| BlackRock Asset Management Ireland Limited |
377,429 |
0.47 |
56,005 |
12/31/20 |
| Tekla Capital Management LLC |
366,176 |
0.46 |
271,938 |
12/31/20 |
| Eversept Partners, LP |
356,235 |
0.44 |
179,477 |
12/31/20 |
| General American Investors Company, Inc. |
347,497 |
0.43 |
-- |
12/31/20 |
| Woodline Partners LP |
324,767 |
0.41 |
324,767 |
12/31/20 |
| Ikarian Capital LLC |
280,989 |
0.35 |
40,000 |
12/31/20 |
| Pinnacle Associates Ltd. |
247,194 |
0.31 |
-16,986 |
12/31/20 |
| BlackRock Investment Management, LLC |
228,606 |
0.29 |
3,514 |
12/31/20 |
| Vantage Consulting Group, Inc. |
226,670 |
0.28 |
226,670 |
12/31/20 |
| Fidelity Institutional Asset Management |
224,043 |
0.28 |
-3,900 |
12/31/20 |
| Norges Bank Investment Management (NBIM) |
223,810 |
0.28 |
-59,695 |
12/31/19 |
| Pictet Asset Management Ltd. |
220,234 |
0.27 |
-8,100 |
12/31/20 |
| Alyeska Investment Group, L.P. |
218,473 |
0.27 |
-337,839 |
12/31/20 |
| Pictet Asset Management (Japan) Ltd. |
216,662 |
0.27 |
81,972 |
4/30/20 |
| Susquehanna International Group, LLP |
211,659 |
0.26 |
-102,565 |
12/31/20 |
| Assenagon Asset Management S.A. |
203,988 |
0.25 |
-271,906 |
12/31/20 |
