| Fidelity Management & Research Company LLC |
11,905,567 |
14.66 |
106,024 |
3/31/21 |
| The Vanguard Group, Inc. |
6,721,693 |
8.28 |
240,349 |
3/31/21 |
| Wasatch Global Investors Inc |
6,525,323 |
8.04 |
191,423 |
3/31/21 |
| BlackRock Institutional Trust Company, N.A. |
5,196,536 |
6.40 |
162,430 |
3/31/21 |
| Alafi Capital Company, LLC |
4,743,770 |
5.84 |
70,500 |
4/1/21 |
| Bellevue Asset Management AG |
3,659,919 |
4.51 |
-- |
3/31/21 |
| Marshall Wace LLP |
2,834,460 |
3.49 |
-661,573 |
3/31/21 |
| Lord, Abbett & Co. LLC |
2,122,140 |
2.61 |
787,944 |
3/31/21 |
| Citadel Advisors LLC |
1,496,006 |
1.84 |
70,320 |
3/31/21 |
| State Street Global Advisors (US) |
1,483,659 |
1.83 |
-128,942 |
3/31/21 |
| Samlyn Capital, LLC |
1,369,606 |
1.69 |
-290,332 |
3/31/21 |
| Schroder Investment Management North America Inc. |
1,322,996 |
1.63 |
9,970 |
3/31/21 |
| TimesSquare Capital Management, LLC |
1,227,280 |
1.51 |
338,080 |
3/31/21 |
| Geode Capital Management, L.L.C. |
1,194,753 |
1.47 |
86,757 |
3/31/21 |
| Alexandria Venture Investments LLC |
1,191,156 |
1.47 |
-- |
4/1/21 |
| Franklin Advisers, Inc. |
1,162,579 |
1.43 |
1,162,579 |
3/31/21 |
| Mates (Sharon) |
1,133,392 |
1.40 |
-- |
4/1/21 |
| Suvretta Capital Management, LLC |
1,038,770 |
1.28 |
132,800 |
3/31/21 |
| Alafi (Christopher D) |
1,020,548 |
1.26 |
-- |
4/1/21 |
| Adage Capital Management, L.P. |
800,000 |
0.99 |
37,583 |
3/31/21 |
| Millennium Management LLC |
798,052 |
0.98 |
-796,101 |
3/31/21 |
| Dimensional Fund Advisors, L.P. |
783,031 |
0.96 |
-394,740 |
3/31/21 |
| Nuveen LLC |
761,758 |
0.94 |
-16,561 |
3/31/21 |
| Northern Trust Investments, Inc. |
669,871 |
0.82 |
-126,397 |
3/31/21 |
| Sofinnova Investments, Inc |
655,001 |
0.81 |
-193,161 |
3/31/21 |
| Nicholas Investment Partners, L.P. |
554,545 |
0.68 |
164,256 |
3/31/21 |
| Norges Bank Investment Management (NBIM) |
527,281 |
0.65 |
-70,159 |
12/31/20 |
| BlackRock Advisors (UK) Limited |
505,300 |
0.62 |
-2,716 |
6/30/21 |
| ClearBridge Investments, LLC |
475,512 |
0.59 |
-146,233 |
3/31/21 |
| Charles Schwab Investment Management, Inc. |
475,134 |
0.59 |
17,172 |
3/31/21 |
| BlackRock Asset Management Ireland Limited |
472,114 |
0.58 |
94,685 |
3/31/21 |
| Rhenman & Partners Asset Management AB |
457,778 |
0.56 |
-42,222 |
3/31/21 |
| Goldman Sachs Asset Management, L.P. |
457,436 |
0.56 |
406,152 |
3/31/21 |
| Macquarie Investment Management |
450,000 |
0.55 |
-- |
3/31/21 |
| Morgan Stanley Smith Barney LLC |
429,445 |
0.53 |
10,635 |
3/31/21 |
| DCF Advisers, LLC |
424,500 |
0.52 |
-- |
3/31/21 |
| Goldman Sachs & Company, Inc. |
359,603 |
0.44 |
-192,848 |
3/31/21 |
| General American Investors Company, Inc. |
347,497 |
0.43 |
-- |
3/31/21 |
| Ikarian Capital LLC |
330,989 |
0.41 |
50,000 |
3/31/21 |
| Candriam Belgium S.A. |
319,487 |
0.39 |
-136,535 |
6/30/21 |
| Riggs (Rory B) |
302,763 |
0.37 |
385 |
6/30/21 |
| Eversept Partners, LP |
300,587 |
0.37 |
-55,648 |
3/31/21 |
| Woodline Partners LP |
294,285 |
0.36 |
-30,482 |
3/31/21 |
| Invesco Capital Management LLC |
285,590 |
0.35 |
277,672 |
3/31/21 |
| Tekla Capital Management LLC |
232,476 |
0.29 |
-133,700 |
3/31/21 |
| Fidelity Institutional Asset Management |
231,955 |
0.29 |
7,912 |
3/31/21 |
| Vantage Consulting Group, Inc. |
226,670 |
0.28 |
-- |
3/31/21 |
| Susquehanna International Group, LLP |
226,249 |
0.28 |
14,590 |
3/31/21 |
| Pinnacle Associates Ltd. |
222,669 |
0.27 |
-24,525 |
3/31/21 |
| BMO Family Office, LLC |
220,301 |
0.27 |
27,175 |
3/31/21 |
