| Fidelity Management & Research Company |
8,270,193 |
14.99 |
2,683 |
6/30/19 |
| Alafi Capital Company, LLC |
4,673,270 |
8.47 |
720,000 |
9/10/19 |
| The Vanguard Group, Inc. |
4,190,181 |
7.59 |
-26,354 |
6/30/19 |
| BlackRock Institutional Trust Company, N.A. |
3,461,947 |
6.27 |
-29,046 |
6/30/19 |
| Wasatch Global Investors Inc |
2,348,032 |
4.26 |
-13,587 |
6/30/19 |
| Bellevue Asset Management AG |
2,245,500 |
4.07 |
45,500 |
6/30/19 |
| Dimensional Fund Advisors, L.P. |
1,709,500 |
3.10 |
86,304 |
6/30/19 |
| Schroder Investment Management North America Inc. |
1,430,469 |
2.59 |
75,757 |
6/30/19 |
| Alexandria Equities, L.L.C. |
1,191,156 |
2.16 |
-- |
4/15/19 |
| Mates (Sharon) |
1,138,707 |
2.06 |
-- |
4/15/19 |
| Samlyn Capital, LLC |
1,032,105 |
1.87 |
-330,981 |
6/30/19 |
| Alafi (Christopher D) |
1,015,800 |
1.84 |
160,824 |
9/30/19 |
| State Street Global Advisors (US) |
999,100 |
1.81 |
8,931 |
6/30/19 |
| Rhenman & Partners Asset Management AB |
949,833 |
1.72 |
-- |
6/30/19 |
| Candriam Belgium S.A. |
918,000 |
1.66 |
-- |
8/31/19 |
| Geode Capital Management, L.L.C. |
644,414 |
1.17 |
31,800 |
6/30/19 |
| Nuveen LLC |
618,254 |
1.12 |
45,602 |
6/30/19 |
| Franklin Advisers, Inc. |
614,700 |
1.11 |
-- |
6/30/19 |
| First Midwest Trust Company |
600,236 |
1.09 |
246,644 |
6/30/19 |
| Columbus Circle Investors |
533,636 |
0.97 |
146,245 |
6/30/19 |
| Northern Trust Investments, Inc. |
518,461 |
0.94 |
6,870 |
6/30/19 |
| Candriam Luxembourg S.A. |
518,000 |
0.94 |
-140,000 |
6/30/19 |
| Morgan Stanley Smith Barney LLC |
450,616 |
0.82 |
7,457 |
6/30/19 |
| Two Sigma Investments, LP |
391,660 |
0.71 |
-25,541 |
6/30/19 |
| T. Rowe Price Associates, Inc. |
355,500 |
0.64 |
-563 |
6/30/19 |
| D. E. Shaw & Co., L.P. |
354,888 |
0.64 |
42,630 |
6/30/19 |
| Citadel LLC |
339,648 |
0.62 |
246,976 |
6/30/19 |
| Norges Bank Investment Management (NBIM) |
330,070 |
0.60 |
-- |
12/31/18 |
| General American Investors Company, Inc. |
299,942 |
0.54 |
-- |
6/30/19 |
| Charles Schwab Investment Management, Inc. |
271,280 |
0.49 |
3,940 |
6/30/19 |
| Riggs (Rory B) |
270,975 |
0.49 |
1,941 |
9/30/19 |
| Deutsche Asset Management Americas |
231,374 |
0.42 |
113,743 |
6/30/19 |
| Numeric Investors LLC |
196,803 |
0.36 |
-46,200 |
6/30/19 |
| BlackRock Financial Management, Inc. |
190,501 |
0.35 |
27,860 |
6/30/19 |
| JP Morgan Asset Management |
177,300 |
0.32 |
400 |
6/30/19 |
| BlackRock Investment Management, LLC |
151,299 |
0.27 |
10,743 |
6/30/19 |
| Nexthera Capital LP |
143,665 |
0.26 |
143,665 |
6/30/19 |
| Pictet Asset Management Ltd. |
137,524 |
0.25 |
-2,576 |
6/30/19 |
| Millennium Management LLC |
135,352 |
0.25 |
-577,306 |
6/30/19 |
| AXA Rosenberg Investment Management LLC |
132,511 |
0.24 |
900 |
6/30/19 |
| DekaBank Deutsche Girozentrale |
131,400 |
0.24 |
51,700 |
6/30/19 |
| Jacobs Levy Equity Management, Inc. |
127,384 |
0.23 |
13,700 |
6/30/19 |
| Sofinnova Investments, Inc |
125,955 |
0.23 |
125,955 |
6/30/19 |
| BNY Mellon Asset Management |
124,921 |
0.23 |
-5,955 |
6/30/19 |
| Parallax Volatility Advisers, L.P. |
118,884 |
0.22 |
22,471 |
6/30/19 |
| Macquarie Investment Management |
107,616 |
0.20 |
32,800 |
6/30/19 |
| Peregrine Capital Management, LLC |
107,616 |
0.20 |
32,800 |
6/30/19 |
| Marcus (Joel S) |
100,413 |
0.18 |
-- |
5/31/19 |
| Schroder Investment Management Ltd. (SIM) |
100,067 |
0.18 |
-- |
7/31/19 |
| Schweizerische Nationalbank |
86,900 |
0.16 |
7,100 |
6/30/19 |