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STOCK INFORMATION

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 192 1,364.68 70.54 45,130,001
Mutual Fund 330 575.12 38.41 23,645,027
Insider 12 76.66 4.75 2,821,960

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 96 262.18 13.03 8,614,863
Sellers 111 -306.70 16.19 -10,704,300
Net -44.51 3.16 -2,089,437

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 1,455.28 77.39 49,101,343
Top 10 Inst. 854.15 47.49 30,133,166
Top 20 Inst. 1,102.76 60.80 38,415,384
Top 50 Inst. 1,355.42 72.52 45,971,297

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 45 212.69 11.45 7,458,546
Aggressive Growth 4 12.51 0.56 364,686
Core Growth 32 105.45 4.86 3,161,463
Growth 9 94.73 6.03 3,932,397
Income 2 3.88 0.18 116,409
Income Value 1 3.71 0.17 107,999
Yield 1 0.18 0.01 8,410
Index 25 372.48 16.65 10,862,027
Other 70 714.07 39.31 24,793,148
Broker Dealer 19 43.17 1.93 1,258,291
GARP 26 434.82 19.90 12,982,281
Hedge Fund 22 180.87 8.11 5,287,618
Specialty 1 0.57 0.03 16,688
VC Private Equity 2 54.64 9.35 5,248,270
Value 23 32.43 1.46 952,087
Core Value 16 23.71 1.06 692,065
Deep Value 7 8.72 0.40 260,022

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 6,303,122 9.66 176,129 12/31/19
Alafi Capital Company, LLC 4,673,270 8.47 720,000 9/10/19
The Vanguard Group, Inc. 4,219,590 6.47 37,460 12/31/19
BlackRock Institutional Trust Company, N.A. 3,514,065 5.39 -12,398 12/31/19
Bellevue Asset Management AG 3,458,419 5.30 1,092,419 1/30/20
Consonance Capital Management LP 1,975,000 3.03 1,955,000 12/31/19
Wasatch Global Investors Inc 1,781,699 2.73 -2,234,061 12/31/19
Dimensional Fund Advisors, L.P. 1,701,373 2.61 -56,974 12/31/19
T. Rowe Price Associates, Inc. 1,293,236 1.98 1,220,658 12/31/19
Mates (Sharon) 1,213,392 1.86 51,207 1/24/20
Alexandria Venture Investments LLC 1,191,156 2.16 -- 4/15/19
State Street Global Advisors (US) 1,113,444 1.71 -43,603 12/31/19
Alafi (Christopher D) 1,016,222 1.84 422 12/31/19
Candriam Luxembourg S.A. 893,000 1.37 -25,000 12/31/19
Candriam Belgium S.A. 893,000 1.37 -- 1/31/20
Schroder Investment Management North America Inc. 752,895 1.15 -675,656 12/31/19
Geode Capital Management, L.L.C. 639,498 0.98 -12,873 12/31/19
Citadel LLC 620,914 0.95 -85,407 12/31/19
Acuta Capital Partners, LLC 587,089 0.90 587,089 12/31/19
VHCP Management, LLC 575,000 0.88 575,000 12/31/19
Northern Trust Investments, Inc. 523,168 0.80 -14,546 12/31/19
Rhenman & Partners Asset Management AB 500,000 0.77 -350,000 12/31/19
Morgan Stanley Smith Barney LLC 473,091 0.73 22,412 12/31/19
DCF Advisers, LLC 468,073 0.72 468,073 12/31/19
Morgan Stanley & Co. LLC 433,020 0.66 86,148 12/31/19
Opaleye Management Inc. 406,600 0.62 236,600 12/31/19
Nuveen LLC 342,564 0.53 100,953 12/31/19
General American Investors Company, Inc. 331,527 0.51 -10,000 12/31/19
ClearBridge Investments, LLC 317,609 0.49 -467,529 12/31/19
Charles Schwab Investment Management, Inc. 279,124 0.43 5,169 12/31/19
Riggs (Rory B) 271,397 0.49 422 12/31/19
Samlyn Capital, LLC 266,700 0.41 -912,983 12/31/19
Millennium Management LLC 259,854 0.40 -977,114 12/31/19
D. E. Shaw & Co., L.P. 231,413 0.35 1,887 12/31/19
Norges Bank Investment Management (NBIM) 223,810 0.34 -106,260 12/31/19
Jacobs Levy Equity Management, Inc. 218,415 0.33 9,788 12/31/19
AXA Rosenberg Investment Management LLC 202,011 0.31 -- 12/31/19
J.P. Morgan Securities LLC 181,771 0.28 181,771 12/31/19
BlackRock Investment Management, LLC 173,314 0.27 -18,791 12/31/19
Goldman Sachs & Company, Inc. 167,107 0.26 78,337 12/31/19
JP Morgan Asset Management 160,725 0.25 -15,900 12/31/19
BlackRock Financial Management, Inc. 158,957 0.24 -42,719 12/31/19
Pictet Asset Management Ltd. 146,824 0.23 800 12/31/19
Nexthera Capital LP 143,665 0.26 143,665 6/30/19
Raymond James & Associates, Inc. 135,200 0.21 44,655 12/31/19
Schroder Investment Management Ltd. (SIM) 118,168 0.18 31,456 1/31/20
Voloridge Investment Management, LLC 111,505 0.17 76,139 12/31/19
BNY Mellon Asset Management 107,999 0.17 -2,666 12/31/19
First Midwest Trust Company 101,889 0.16 101,889 12/31/19
Marcus (Joel S) 100,413 0.18 -- 5/31/19

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