| Fidelity Management & Research Company LLC |
10,263,601 |
10.84 |
-63,066 |
9/30/22 |
| The Vanguard Group, Inc. |
8,100,645 |
8.55 |
35,822 |
9/30/22 |
| BlackRock Institutional Trust Company, N.A. |
5,963,976 |
6.30 |
-49,824 |
9/30/22 |
| Wellington Management Company, LLP |
5,158,750 |
5.45 |
695,392 |
9/30/22 |
| Alafi Capital Company, LLC |
4,743,770 |
5.01 |
-- |
4/1/22 |
| Wasatch Global Investors Inc |
4,740,145 |
5.01 |
-503,145 |
12/31/22 |
| Bellevue Asset Management AG |
3,329,279 |
3.52 |
-20,100 |
9/30/22 |
| AllianceBernstein L.P. |
2,200,408 |
2.32 |
87,821 |
9/30/22 |
| Lord, Abbett & Co. LLC |
2,018,686 |
2.13 |
167,737 |
9/30/22 |
| State Street Global Advisors (US) |
1,976,223 |
2.09 |
56,408 |
9/30/22 |
| Millennium Management LLC |
1,841,049 |
1.94 |
803,772 |
9/30/22 |
| Franklin Advisers, Inc. |
1,783,950 |
1.88 |
97,480 |
9/30/22 |
| Invesco Advisers, Inc. |
1,654,221 |
1.75 |
1,002,967 |
9/30/22 |
| Geode Capital Management, L.L.C. |
1,618,310 |
1.71 |
29,911 |
9/30/22 |
| Holocene Advisors, LP |
1,591,383 |
1.68 |
-36,025 |
9/30/22 |
| GW&K Investment Management, LLC |
1,465,835 |
1.55 |
882,242 |
9/30/22 |
| Avidity Partners Management LP |
1,402,500 |
1.48 |
626,996 |
9/30/22 |
| Mates (Sharon) |
1,061,384 |
1.12 |
-33,083 |
12/13/22 |
| TimesSquare Capital Management, LLC |
885,510 |
0.94 |
84,672 |
9/30/22 |
| Schroder Investment Management North America Inc. |
877,537 |
0.93 |
37,021 |
9/30/22 |
| Suvretta Capital Management, LLC |
851,958 |
0.90 |
-486,742 |
9/30/22 |
| Alafi (Christopher D) |
850,548 |
0.90 |
-170,000 |
4/1/22 |
| Pictet Asset Management Ltd. |
844,924 |
0.89 |
-268,658 |
9/30/22 |
| Northern Trust Investments, Inc. |
743,723 |
0.79 |
-8,833 |
9/30/22 |
| Dimensional Fund Advisors, L.P. |
730,882 |
0.77 |
-22,886 |
9/30/22 |
| Charles Schwab Investment Management, Inc. |
680,459 |
0.72 |
54,695 |
9/30/22 |
| Point72 Asset Management, L.P. |
655,800 |
0.69 |
655,800 |
9/30/22 |
| ClearBridge Investments, LLC |
651,283 |
0.69 |
446,112 |
9/30/22 |
| Hood River Capital Management LLC |
643,865 |
0.68 |
11,877 |
9/30/22 |
| Tang Capital Management, LLC |
640,000 |
0.68 |
-60,000 |
9/30/22 |
| Polar Capital LLP |
604,250 |
0.64 |
-284,287 |
9/30/22 |
| Norges Bank Investment Management (NBIM) |
583,207 |
0.62 |
225,619 |
12/31/21 |
| Samlyn Capital, LLC |
537,888 |
0.57 |
75,073 |
9/30/22 |
| Nuveen LLC |
531,142 |
0.56 |
-72,504 |
9/30/22 |
| Goldman Sachs & Company, Inc. |
519,220 |
0.55 |
15,810 |
9/30/22 |
| Morgan Stanley Smith Barney LLC |
508,796 |
0.54 |
101,405 |
9/30/22 |
| Macquarie Investment Management |
451,920 |
0.48 |
-74,053 |
9/30/22 |
| DWS Investment GmbH |
449,556 |
0.47 |
-8,722 |
9/30/22 |
| BlackRock Financial Management, Inc. |
412,040 |
0.44 |
83,346 |
9/30/22 |
| Nicholas Investment Partners, L.P. |
390,678 |
0.41 |
-43,281 |
9/30/22 |
| SEB Investment Management AB |
383,565 |
0.41 |
-- |
9/30/22 |
| BlackRock Advisors (UK) Limited |
364,669 |
0.39 |
15,878 |
12/31/22 |
| D. E. Shaw & Co., L.P. |
350,078 |
0.37 |
11,417 |
9/30/22 |
| JPMorgan Asset Management U.K. Limited |
348,669 |
0.37 |
94,898 |
12/31/22 |
| BlackRock Asset Management Ireland Limited |
340,342 |
0.36 |
-2,457 |
9/30/22 |
| Kennedy Capital Management, Inc. |
323,609 |
0.34 |
70,290 |
9/30/22 |
| American Century Investment Management, Inc. |
317,795 |
0.34 |
-1,504 |
9/30/22 |
| T. Rowe Price Associates, Inc. |
305,850 |
0.32 |
265,108 |
9/30/22 |
| Adage Capital Management, L.P. |
305,000 |
0.32 |
-698,271 |
9/30/22 |
| Victory Capital Management Inc. |
295,395 |
0.31 |
-839,455 |
9/30/22 |
