| Fidelity Management & Research Company LLC |
10,896,481 |
11.55 |
-8,163 |
3/31/22 |
| The Vanguard Group, Inc. |
7,788,469 |
8.26 |
912,268 |
3/31/22 |
| Wasatch Global Investors Inc |
7,477,868 |
7.93 |
-757,303 |
3/31/22 |
| BlackRock Institutional Trust Company, N.A. |
5,428,450 |
5.76 |
670,166 |
3/31/22 |
| Alafi Capital Company, LLC |
4,743,770 |
5.03 |
-- |
4/1/22 |
| Wellington Management Company, LLP |
4,061,160 |
4.31 |
3,125,572 |
3/31/22 |
| Bellevue Asset Management AG |
3,429,619 |
3.64 |
-199,300 |
3/31/22 |
| Marshall Wace LLP |
2,519,764 |
2.67 |
131,470 |
3/31/22 |
| Lord, Abbett & Co. LLC |
1,981,356 |
2.10 |
-149,464 |
3/31/22 |
| State Street Global Advisors (US) |
1,792,530 |
1.90 |
269,892 |
3/31/22 |
| Franklin Advisers, Inc. |
1,686,032 |
1.79 |
605,418 |
3/31/22 |
| Suvretta Capital Management, LLC |
1,531,923 |
1.62 |
279,977 |
3/31/22 |
| Pictet Asset Management Ltd. |
1,485,488 |
1.57 |
30,614 |
3/31/22 |
| Geode Capital Management, L.L.C. |
1,470,957 |
1.56 |
185,143 |
3/31/22 |
| Mates (Sharon) |
1,094,467 |
1.16 |
-38,925 |
4/1/22 |
| Schroder Investment Management North America Inc. |
983,913 |
1.04 |
-195,926 |
3/31/22 |
| Victory Capital Management Inc. |
932,322 |
0.99 |
905,732 |
3/31/22 |
| TimesSquare Capital Management, LLC |
877,028 |
0.93 |
-466,937 |
3/31/22 |
| Alafi (Christopher D) |
850,548 |
0.90 |
-170,000 |
4/1/22 |
| Adage Capital Management, L.P. |
850,000 |
0.90 |
600,000 |
3/31/22 |
| Dimensional Fund Advisors, L.P. |
744,880 |
0.79 |
-44,939 |
3/31/22 |
| Millennium Management LLC |
725,469 |
0.77 |
92,312 |
3/31/22 |
| Holocene Advisors, LP |
722,724 |
0.77 |
722,724 |
3/31/22 |
| Nuveen LLC |
715,876 |
0.76 |
81,989 |
3/31/22 |
| Northern Trust Investments, Inc. |
708,418 |
0.75 |
51,333 |
3/31/22 |
| Tang Capital Management, LLC |
700,000 |
0.74 |
700,000 |
3/31/22 |
| Charles Schwab Investment Management, Inc. |
607,737 |
0.64 |
89,260 |
3/31/22 |
| Citadel Advisors LLC |
599,032 |
0.64 |
-151,684 |
3/31/22 |
| Norges Bank Investment Management (NBIM) |
583,207 |
0.62 |
302,172 |
12/31/21 |
| Brandywine Global Investment Management, LLC |
568,811 |
0.60 |
-6,167 |
3/31/22 |
| Nicholas Investment Partners, L.P. |
562,373 |
0.60 |
-90,513 |
3/31/22 |
| GW&K Investment Management, LLC |
549,327 |
0.58 |
176,007 |
3/31/22 |
| Polar Capital LLP |
521,443 |
0.55 |
429,708 |
3/31/22 |
| Hood River Capital Management LLC |
510,830 |
0.54 |
510,830 |
3/31/22 |
| BlackRock Advisors (UK) Limited |
489,258 |
0.52 |
-2,688 |
5/31/22 |
| Driehaus Capital Management, LLC |
488,460 |
0.52 |
488,460 |
3/31/22 |
| Samlyn Capital, LLC |
484,103 |
0.51 |
-625,752 |
3/31/22 |
| BlackRock Asset Management Ireland Limited |
472,611 |
0.50 |
-40,703 |
3/31/22 |
| Morgan Stanley Smith Barney LLC |
459,850 |
0.49 |
10,734 |
3/31/22 |
| DWS Investment GmbH |
458,557 |
0.49 |
-11,235 |
3/31/22 |
| Macquarie Investment Management |
450,000 |
0.48 |
-- |
3/31/22 |
| SEB Investment Management AB |
391,937 |
0.42 |
-4,342 |
3/31/22 |
| Goldman Sachs & Company, Inc. |
378,845 |
0.40 |
263,283 |
3/31/22 |
| Russell Investments Trust Company |
373,339 |
0.40 |
42,480 |
3/31/22 |
| D. E. Shaw & Co., L.P. |
364,618 |
0.39 |
211,031 |
3/31/22 |
| SilverArc Capital Management, LLC |
308,819 |
0.33 |
113,819 |
3/31/22 |
| Tekla Capital Management LLC |
290,936 |
0.31 |
54,489 |
3/31/22 |
| Invesco Advisers, Inc. |
289,957 |
0.31 |
259,373 |
3/31/22 |
| BMO Family Office, LLC |
289,288 |
0.31 |
586 |
3/31/22 |
| General American Investors Company, Inc. |
283,439 |
0.30 |
-- |
3/31/22 |
