STOCK INFORMATION

Shareholder Breakdown

Shareholder	Holders	Value ($MM)	% O/S	Shares
Institution	192	1,364.68	70.54	45,130,001
Mutual Fund	330	575.12	38.41	23,645,027
Insider	12	76.66	4.75	2,821,960

Institutional Shareholder Rotation

Shareholder	Holders	Value Chg ($MM)	% O/S	Share Change
Buyers	96	262.18	13.03	8,614,863
Sellers	111	-306.70	16.19	-10,704,300
Net		-44.51	3.16	-2,089,437

Institutional Shareholder Concentration

	Value ($MM)	% O/S	Shares
Total Inst.	1,455.28	77.39	49,101,343
Top 10 Inst.	854.15	47.49	30,133,166
Top 20 Inst.	1,102.76	60.80	38,415,384
Top 50 Inst.	1,355.42	72.52	45,971,297

Institutional Shareholder Style

	Holders	Value ($MM)	% Inst Shares	Shares
Growth	45	212.69	11.45	7,458,546
Aggressive Growth	4	12.51	0.56	364,686
Core Growth	32	105.45	4.86	3,161,463
Growth	9	94.73	6.03	3,932,397
Income	2	3.88	0.18	116,409
Income Value	1	3.71	0.17	107,999
Yield	1	0.18	0.01	8,410
Index	25	372.48	16.65	10,862,027
Other	70	714.07	39.31	24,793,148
Broker Dealer	19	43.17	1.93	1,258,291
GARP	26	434.82	19.90	12,982,281
Hedge Fund	22	180.87	8.11	5,287,618
Specialty	1	0.57	0.03	16,688
VC Private Equity	2	54.64	9.35	5,248,270
Value	23	32.43	1.46	952,087
Core Value	16	23.71	1.06	692,065
Deep Value	7	8.72	0.40	260,022

Top Holders: Institutional Investor

Holder	Shares Held	% O/S	Share Change	Filing Date
Fidelity Management & Research Company	6,303,122	9.66	176,129	12/31/19
Alafi Capital Company, LLC	4,673,270	8.47	720,000	9/10/19
The Vanguard Group, Inc.	4,219,590	6.47	37,460	12/31/19
BlackRock Institutional Trust Company, N.A.	3,514,065	5.39	-12,398	12/31/19
Bellevue Asset Management AG	3,458,419	5.30	1,092,419	1/30/20
Consonance Capital Management LP	1,975,000	3.03	1,955,000	12/31/19
Wasatch Global Investors Inc	1,781,699	2.73	-2,234,061	12/31/19
Dimensional Fund Advisors, L.P.	1,701,373	2.61	-56,974	12/31/19
T. Rowe Price Associates, Inc.	1,293,236	1.98	1,220,658	12/31/19
Mates (Sharon)	1,213,392	1.86	51,207	1/24/20
Alexandria Venture Investments LLC	1,191,156	2.16	--	4/15/19
State Street Global Advisors (US)	1,113,444	1.71	-43,603	12/31/19
Alafi (Christopher D)	1,016,222	1.84	422	12/31/19
Candriam Luxembourg S.A.	893,000	1.37	-25,000	12/31/19
Candriam Belgium S.A.	893,000	1.37	--	1/31/20
Schroder Investment Management North America Inc.	752,895	1.15	-675,656	12/31/19
Geode Capital Management, L.L.C.	639,498	0.98	-12,873	12/31/19
Citadel LLC	620,914	0.95	-85,407	12/31/19
Acuta Capital Partners, LLC	587,089	0.90	587,089	12/31/19
VHCP Management, LLC	575,000	0.88	575,000	12/31/19
Northern Trust Investments, Inc.	523,168	0.80	-14,546	12/31/19
Rhenman & Partners Asset Management AB	500,000	0.77	-350,000	12/31/19
Morgan Stanley Smith Barney LLC	473,091	0.73	22,412	12/31/19
DCF Advisers, LLC	468,073	0.72	468,073	12/31/19
Morgan Stanley & Co. LLC	433,020	0.66	86,148	12/31/19
Opaleye Management Inc.	406,600	0.62	236,600	12/31/19
Nuveen LLC	342,564	0.53	100,953	12/31/19
General American Investors Company, Inc.	331,527	0.51	-10,000	12/31/19
ClearBridge Investments, LLC	317,609	0.49	-467,529	12/31/19
Charles Schwab Investment Management, Inc.	279,124	0.43	5,169	12/31/19
Riggs (Rory B)	271,397	0.49	422	12/31/19
Samlyn Capital, LLC	266,700	0.41	-912,983	12/31/19
Millennium Management LLC	259,854	0.40	-977,114	12/31/19
D. E. Shaw & Co., L.P.	231,413	0.35	1,887	12/31/19
Norges Bank Investment Management (NBIM)	223,810	0.34	-106,260	12/31/19
Jacobs Levy Equity Management, Inc.	218,415	0.33	9,788	12/31/19
AXA Rosenberg Investment Management LLC	202,011	0.31	--	12/31/19
J.P. Morgan Securities LLC	181,771	0.28	181,771	12/31/19
BlackRock Investment Management, LLC	173,314	0.27	-18,791	12/31/19
Goldman Sachs & Company, Inc.	167,107	0.26	78,337	12/31/19
JP Morgan Asset Management	160,725	0.25	-15,900	12/31/19
BlackRock Financial Management, Inc.	158,957	0.24	-42,719	12/31/19
Pictet Asset Management Ltd.	146,824	0.23	800	12/31/19
Nexthera Capital LP	143,665	0.26	143,665	6/30/19
Raymond James & Associates, Inc.	135,200	0.21	44,655	12/31/19
Schroder Investment Management Ltd. (SIM)	118,168	0.18	31,456	1/31/20
Voloridge Investment Management, LLC	111,505	0.17	76,139	12/31/19
BNY Mellon Asset Management	107,999	0.17	-2,666	12/31/19
First Midwest Trust Company	101,889	0.16	101,889	12/31/19
Marcus (Joel S)	100,413	0.18	--	5/31/19