STOCK INFORMATION

Shareholder Breakdown

Shareholder	Holders	Value ($MM)	% O/S	Shares
Institution	184	391.76	82.56	45,878,023
Mutual Fund	321	401.42	43.24	23,889,599
Insider	12	77.43	4.73	2,804,807

Institutional Shareholder Rotation

Shareholder	Holders	Value Chg ($MM)	% O/S	Share Change
Buyers	93	69.51	13.11	8,552,132
Sellers	95	-63.64	10.16	-6,628,853
Net		5.87	2.95	1,923,279

Institutional Shareholder Concentration

	Value ($MM)	% O/S	Shares
Total Inst.	484.88	89.45	49,873,986
Top 10 Inst.	249.09	55.31	30,742,179
Top 20 Inst.	378.30	71.73	39,951,017
Top 50 Inst.	454.17	83.69	46,651,458

Institutional Shareholder Style

	Holders	Value ($MM)	% Inst Shares	Shares
Growth	46	52.40	12.39	6,851,708
Aggressive Growth	4	2.08	0.50	278,679
Core Growth	34	27.28	6.33	3,498,730
Growth	8	23.04	5.56	3,074,299
Income	3	1.19	0.24	130,218
Income Value	2	0.91	0.22	122,164
Yield	1	0.28	0.01	8,054
Index	24	82.67	19.66	10,872,111
Other	66	237.63	47.28	26,347,277
Broker Dealer	16	6.93	1.61	903,552
GARP	23	139.57	27.00	15,060,069
Hedge Fund	25	55.94	10.13	5,674,536
Specialty	1	0.27	0.06	35,850
VC Private Equity	1	34.91	8.47	4,673,270
Value	18	12.08	1.91	1,069,743
Core Value	14	10.09	1.44	810,640
Deep Value	4	1.99	0.47	259,103

Top Holders: Institutional Investor

Holder	Shares Held	% O/S	Share Change	Filing Date
Fidelity Management & Research Company	6,126,993	11.09	-2,143,200	9/30/19
Alafi Capital Company, LLC	4,673,270	8.47	720,000	9/10/19
The Vanguard Group, Inc.	4,182,130	7.57	-8,051	9/30/19
Wasatch Global Investors Inc	4,015,760	7.27	1,667,728	9/30/19
BlackRock Institutional Trust Company, N.A.	3,526,463	6.38	64,516	9/30/19
Bellevue Asset Management AG	2,588,990	4.69	343,490	9/30/19
Dimensional Fund Advisors, L.P.	1,758,347	3.18	48,847	9/30/19
Schroder Investment Management North America Inc.	1,428,551	2.59	-1,918	9/30/19
Millennium Management LLC	1,236,968	2.24	1,101,616	9/30/19
Mates (Sharon)	1,204,707	1.85	42,522	1/9/20
Alexandria Venture Investments LLC	1,191,156	2.16	--	4/15/19
Samlyn Capital, LLC	1,179,683	2.13	147,578	9/30/19
State Street Global Advisors (US)	1,157,047	2.09	157,947	9/30/19
Candriam Belgium S.A.	1,068,000	1.93	150,000	11/30/19
Alafi (Christopher D)	1,016,222	1.84	422	12/31/19
Candriam Luxembourg S.A.	893,000	1.37	-25,000	12/31/19
ClearBridge Investments, LLC	785,138	1.42	777,317	9/30/19
Citadel LLC	706,321	1.28	366,673	9/30/19
Geode Capital Management, L.L.C.	652,371	1.18	7,957	9/30/19
Point72 Asset Management, L.P.	559,900	1.01	559,900	9/30/19
Northern Trust Investments, Inc.	537,714	0.97	19,253	9/30/19
Rhenman & Partners Asset Management AB	500,000	0.77	-350,000	12/31/19
Morgan Stanley Smith Barney LLC	450,679	0.82	63	9/30/19
Morgan Stanley & Co. LLC	346,872	0.63	336,019	9/30/19
General American Investors Company, Inc.	341,527	0.62	41,585	9/30/19
Two Sigma Investments, LP	337,787	0.61	-53,873	9/30/19
Norges Bank Investment Management (NBIM)	330,070	0.60	--	12/31/18
Charles Schwab Investment Management, Inc.	273,955	0.50	2,675	9/30/19
Riggs (Rory B)	271,397	0.49	422	12/31/19
Nuveen LLC	241,611	0.44	-376,643	9/30/19
D. E. Shaw & Co., L.P.	229,526	0.42	-125,362	9/30/19
Jacobs Levy Equity Management, Inc.	208,627	0.38	81,243	9/30/19
AXA Rosenberg Investment Management LLC	202,011	0.37	69,500	9/30/19
BlackRock Financial Management, Inc.	201,676	0.37	11,175	9/30/19
BlackRock Investment Management, LLC	192,105	0.35	40,806	9/30/19
JP Morgan Asset Management	176,625	0.32	-675	9/30/19
Deutsche Asset Management Americas	175,719	0.32	-55,655	9/30/19
Opaleye Management Inc.	170,000	0.31	170,000	9/30/19
Squarepoint Capital LLP	147,257	0.27	93,712	9/30/19
Pictet Asset Management Ltd.	146,024	0.26	8,500	9/30/19
A.R.T. Advisors, LLC	143,921	0.26	110,700	9/30/19
Nexthera Capital LP	143,665	0.26	143,665	6/30/19
PDT Partners, LLC	129,741	0.23	84,537	9/30/19
Schroder Investment Management Ltd. (SIM)	129,103	0.23	--	11/30/19
Jefferies LLC	120,399	0.22	113,387	9/30/19
Verition Fund Management LLC	118,091	0.21	118,091	9/30/19
Ohio Public Employees Retirement System	112,655	0.20	41,393	9/30/19
BNY Mellon Asset Management	110,665	0.20	-14,256	9/30/19
Pura Vida Investments, LLC	109,130	0.20	109,130	9/30/19
First Midwest Trust Company	101,889	0.16	101,889	12/31/19